At 16, Neil Patrick Harris became a household name as a teenage genius physician in Doogie Howser, M.D. (1989). For years, it seemed he'd never escape the role.
He did, spectacularly. He played the scene-stealing Barney Stinson on How I Met Your Mother, won a Tony Award for Hedwig and the Angry Inch, and hosted the Tonys, the Emmys and the Oscars.